2-(4-氯苯基)-6-硝基-1H-苯并[d]咪唑

2-(4-氯苯基)-6-硝基-1H-苯并[d]咪唑 - Names and Identifiers

Name	2-(4-Chlorophenyl)-5-nitrobenziMidazole
Synonyms	PPK1-IN-8 GABAA receptor agent 1 2-(4-Chlorophenyl)-5-nitrobenziMidazole 1H-Benzimidazole, 2-(4-chlorophenyl)-6-nitro- 2-(4-Chloro-phenyl)-5-nitro-1H-benzoimidazole 2-(4-Chlorophenyl)-6-nitro-1H-1,3-benzodiazole
CAS	1571-87-5

2-(4-氯苯基)-6-硝基-1H-苯并[d]咪唑 - Physico-chemical Properties

Molecular Formula	C13H8ClN3O2
Molar Mass	273.67
Solubility	( < 1 mg/ml refers to the product slightly soluble or insoluble)
Storage Condition	-20℃
In vivo study	GABAA receptor agent 1 (30 mg/kg; intraperitoneal) inhibits the maximum electroshock (MES) and pentylenetetrazole (PTZ)-induced convulsions in swiss albino rats.

2-(4-氯苯基)-6-硝基-1H-苯并[d]咪唑 - Reference

Reference

1. Jain P, et al. Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity. Arch Pharm Res. 2010 Jul;33(7):971-80.

2-(4-氯苯基)-6-硝基-1H-苯并[d]咪唑 - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	3.654 ml	18.27 ml	36.54 ml
5 mM	0.731 ml	3.654 ml	7.308 ml
10 mM	0.365 ml	1.827 ml	3.654 ml
5 mM	0.073 ml	0.365 ml	0.731 ml

Last Update：2024-01-02 23:10:35

2-(4-氯苯基)-6-硝基-1H-苯并[d]咪唑 - Reference Information

biological activity

GABAA receptor agent 1 is a high affinity ligand of GABAA receptor, which has strong anticonvulsant activity.

Last Update：2024-04-09 21:04:16

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